COVID-19 infection is a multisystem disease not restricted to the lungs. It may have a negative impact on the cardiovascular system by potentially causing myocardial damage, vascular inflammation, and myocardial infarction. The presence of myocardial injury is a poor prognostic sign. Electrocardiogram, a simple bedside diagnostic test with high prognostic value, can be employed to assess early cardiovascular involvement in such patients. Various abnormalities in ECG like QRS complex and QTc interval prolongation, ST-T changes, arrhythmia, and conduction defects have been reported in COVID-19. In this podcast, cardiology intensivist Dr. Nicola Cosentino will discuss the central role of ECG in the setting of COVID-19 patients. In particular, this podcast will highlight the impact of COVID-19 on ECG findings and on the risk of acute and life-threatening rhythm disorders.